Its not perfect, but have you looked in the PMDX-416 User's Manual in sections 2.5, 2.6 and 2.7? If that doesn't give you enough information, tell us what information is missing and we'll see what we can do. Do your motor drivers have drastically different connections?
Since the PMDX-416 has its screw terminals labeled like an old-style parallel port, perhaps some historical references would be helpful. Here are the typical uses for parallel port pin numbers:
Pins 2 through 9: 4 pairs of step and direction signals. Pins 2 and 3 are one motor, 4 and 5 another motor, etc. One of the pair of pins is the "step" (or pulse) signal, the other pin is the direction. It is your choice which is which, just make sure that Mach4 is configured to match your wiring scheme.
Pins 1, 14, 16 and 17 are general purpose outputs. For older systems, pin 17 was often used for a "charge pump" safety signal. With the PMDX-416 that is not needed (and I think not even available in the plug-in). Pins 14 and 16 are typically used for PWM spindle speed control, if you intend to control spindle speed. Pin 1 drives the relay on the PMDX-416, so is usually used to power the spindle or other accessory.
Pin 10 is usually used as the E-Stop input
Pins 11, 12, 13 and 15 are general purpose inputs, typically used for limit and home switches and/or touch probes.
If you haven't yet, install the PMDX driver along with the sample profiles, plug in the board and run Mach4. **MAKE A COPY** of the PMDX-Sample profile and use that copy. Look around the plug-in configuration and the Mach4 configuration dialogs to get a feel for where you configure the motor step and direction pins and other signals.