I can't yet replicate you issues, though I haven't yet run on our Win10 PC.
Meanwhile, a few things:
(1) Please copy your profile to something other than Mach4Mill. If/when you install a new version of Mach4, that profile WILL get overwritten with the default Mach4Mill profile. Open the Mach4 Loader, highlight "Mach4Mill" and then click on the "Copy Profile" button. Give it some other name. You can leave the screen set field blank and it will use the current screen set. Or if you are Windows-saavy you can simply copy to Mach4HobbyProfilesMach4Mill directory to some other name and change your desktop shortcut (if you have one) to use that new directory.
(2) In a similar fashion, if you have made any changes to the default wx4 screen set you should copy the screen set to some other name and use that. Unfortunately, there is no easy way to merge changes from a new version of the wx4 screen set into your custom version.
(3) You have the SIM plug-in enabled. Please disable it. In older versions of Mach4 having SIM and our plug-in enabled at the same time definitely caused problems. Supposedly in build 2914 that shouldn't happen. However, unless there is a specific reason you have it enabled (and please let me know why) it is better to disable it.
(4) If you still experience crashes with the SIM plug-in disabled, try also disabling the ShuttlePro plug-in. I don't really expect that this is a cause or contributor to the problem, but it is a quick and easy test you can run while we try more tests on our end.
(5) If you feel adventurous, and *AFTER* you have renamed your profile and screen set (if you changed it), you can try installing the latest version of Mach4 (build 3206). Make a copy of your Mach4Hobby directory before installing 3206 so you have an easy fallback in case something goes haywire.
Bob